This reduces delivery of metabolic substrates needed to maintain cellular function. All tissues are underperfused when blood viscosity is elevated. Therapeutic plasma exchange is the therapy of choice for reducing blood viscosity and restoring normal perfusion. Diastolic dysfunction, another common complication of coronavirus 2019, is a consequence of this hypoperfusion. Perfusion is inversely proportional to blood viscosity. In the early twentieth century, Osler noted right ventricular dilation, a common complication of coronavirus 2019, in response to hyperviscosity caused by infection. Coronary thrombosis occurs in association with several infectious diseases and even immunization. These increase erythrocyte aggregation which causes sludging of blood in areas of low shear in the coronary circulation, veins and microvasculature. This hyperviscosity is caused by high concentrations of acute phase reactants, especially fibrinogen, and immunoglobins. The cardiac complications of coronavirus 2019 are most commonly caused by hyperviscosity, not viral invasion of endothelial cells or cardiomyocytes. This phenomenon is fully expressed in coronavirus 2019. Email: Telephone: +1-76 Received: JRevised: JAccepted: JPublished online: August 31, 2021 Cyr, MD, PhD, Jacqmar, Inc, 12683 Drake St. See: http: ///licenses/by-nc/4.0/ Correspondence to: John A. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. Minneapolis, Minnesota, USA.Ĭonflict-of-interest statement: The author(s) declare(s) that there is no conflict of interest regarding the publication of this paper. Cyr4ġ Idaho College of Osteopathic Medicine, Meridian, Idaho, USA Ģ Radboud University Medical Center, Nijmegen, The Netherlands Ĥ Jacqmar, Inc. ![]() The Detrimental Role of Elevated Blood Viscosity in Patients With COVID-19
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